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Nowadays, many novel methods have been invented to treat CHD. He and He [ 31 ] found that resveratrol reduced mitochondrial damage in myocardial cells, inhibited inflammatory reaction, and reduced myocardial cell apoptosis. Vascular endothelial cells can express Notch1, Notch4, delta-like 4 Dll4 , etc. Dysfunction of energy metabolism in myocardial cells is an important pathological basis of myocardial ischemia [ 27 ], and maintaining the functional stability of mitochondria in myocardial cells and the metabolic balance of ATP can effectively alleviate myocardial injury [ 29 , 30 ]. The levels of Bax, caspase 3, and caspase 9 in the model group were much higher compared to those in the control, sham-operated, high-, medium-, and low-dose XBTYF groups, whereas Bcl2 expression was decreased Figure 4 b. From Figure 2 , we observed that the myocardial cells in the control and sham-operated rats were neatly arranged and uniform, without red ischemic changes. Next, the rats were depilated and disinfected with iodine alcohol.

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Introduction Coronary heart disease CHD is characterized by myocardial ischemia, hypoxia, and necrosis.

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Adenosine triphosphate ATP is the main form of energy used by the heart, but because the energy reserve of the heart is very small, ATP must be synthesized efficiently and promptly [ 27 ]. Academic Editor: Mario Ledda. Myocardial cells in the control and sham-operated rats were neatly arranged and uniform, without red ischemic changes. Therefore, researchers have proposed that in vitro intervention can promote the secretion of vascular growth factors and the upregulation of related receptors, thereby establishing effective collateral circulation to meet the needs of heart blood supply. Regretfully, many studies have reported [ 4 — 7 ] that 3D GFs containing a significant fraction of cross-linked, single-layer graphene sheets with extremely sharp edges can physically damage the wall membrane of cells. The sham-operated rats were only subjected to the operative line without ligation. From Figure 1 , we observed that rats in the model group showed significant increases in ST segment in II, III, and aVF compared with those of the control and sham-operated rats, indicating that the myocardial injury model was constructed successfully.

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